NEWS
22/04/2015
Anatomical Model of the Human Head and Neck

MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck

Maria Iacono, Esra Neufeld, Esther Akinnagbe, Kelsey Bower, Johanna Wolf, Ioannis Oikonomidis, Deepika Sharma, Bryn Lloyd, Bertram Wilm, Michael Wyss, Klaas Pruessmann, Andras Jakab, Nikos Makris, Ethan Cohen, Niels Kuster, Wolfgang Kainz, and Leonardo Angelone, PLoS ONE, Volume 10, Issue 4, online April 22, 2015

Computational modelling and simulations are increasingly being used to complement experimental testing for analysis of safety and efficacy of medical devices. We have developed a multimodal imaging-based detailed anatomical model of the human head and neck. The model was obtained by integrating three different magnetic resonance imaging (MRI) modalities, the parameters of which were tailored to enhance the signals of specific tissues: i) structural T1- and T2-weighted MRIs; a specific heavily T2-weighted MRI slab with high nerve contrast optimized to enhance the structures of the ear and eye; ii) magnetic resonance angiography (MRA) data to image the vasculature, and iii) diffusion tensor imaging (DTI) to obtain information on anisotropy and fibre orientation. The unique multimodal high-resolution approach allowed resolving 150 structures, including several distinct muscles, bones and skull layers, arteries and veins, as well as salivary glands. The model offers also a detailed characterization of eyes, ears, and deep brain structures. A special automatic atlas-based segmentation procedure was adopted to include a detailed map of the nuclei of the thalamus and midbrain into the head model. The suitability of the model to simulations involving different numerical methods, discretization approaches, as well as DTI-based tensorial electrical conductivity, was examined in a case-study, in which transcranial alternating current stimulation was modelled.

The scientific and technical impact of the study can be summarized as:

  • Creating and making available a detailed, high-resolution head model distinguishing a large number of tissues
  • Creating high element-quality, topologically conforming, non-intersecting surfaces suitable for structured and unstructured discretization techniques
  • Integrating image-based information to inform on inhomogeneous and anisotropic property distributions
  • Demonstrating the suitability of the head model for a large range of numerical simulation techniques
 
 
 
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PAPERS

22/11/2010

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balzano@itis-usa.org

 

Novel Methodology to Characterize Electromagnetic Exposure of the Brain

Pedro Crespo-Valero, Maria Christopoulou, Marcel Zefferer, Andreas Christ, Peter Achermann, Konstantina S. Nikita, and Niels Kuster, in Physics in Medicine and Biology, Volume 56, Number 2, pp. 383–396, January 2011, online December 22, 2010

 
PAPERS

16/11/2010

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balzano@itis-usa.org

 

Development and Validation of a Magneto-hydrodynamic Solver for Blood Flow Analysis

Wolfgang Kainz, Joshua W. Guag, Stefan Benkler, Dominik Szczerba, Esra Neufeld, Victor Krauthamer, Joel Myklebust, Howard I. Bassen, Isaac A Chang, Nicolas Chavannes, Jung Hwan Kim, Malisa Sarntinoranont, and Niels Kuster, in Physics in Medicine and Biology, Volume 55, Issue 23, pp. 7253–7261, December 2010, online November 16

 
PAPERS

15/11/2010

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balzano@itis-usa.org

 

Evaluation of Measurement Techniques to Show Compliance With RF Safety Limits in Heterogeneous Field Distributions

Sven Kühn and Niels Kuster, in IEEE Transactions on Electromagnetic Compatibility, Volume 52, Issue 4, pp. 820–828, November 2010, online November 15

 
PAPERS

18/10/2010

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balzano@itis-usa.org

 

Analysis of Proteome Response to the Mobile Phone Radiation in Two Types of Human Primary Endothelial Cells

Reetta Nylund, Niels Kuster, and Dariusz Leszczynski, in Proteome Science, Volume 8, Article 52, online 18 October 2010

 
OTHER NEWS

10/10/2010

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balzano@itis-usa.org

 

1st Board Meeting

IT'IS USA held its first board meeting on October 11, 2010, in Maryland.

 
PAPERS

20/09/2010

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balzano@itis-usa.org

 

Sleep After Mobile Phone Exposure in Subjects With Mobile Phone-Related Symptoms

Arne Lowden, Torbjörn Akerstedt, Michael Ingre, Clairy Wiholm, Lena Hillert, Niels Kuster, Jens P. Nilsson, and Bengt Arnetz, in Bioelectromagnetics, Volume 32, Issue 1, pp. 4–14, online September 20, 2010

 
PAPERS

31/08/2010

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balzano@itis-usa.org

 

The Influence of the Reflective Environment on the Absorption of a Human Male Exposed to Representative Base Station Antennas from 300 MHz to 5 GHz

Günter Vermeeren, Marie-Christine Gosselin, Sven Kühn, Valpré Kellerman, Abdelhamid Hadjem, Azeddine Gati, Wout Joseph, Joe Wiart, Frans Meyer, Niels Kuster, and Luc Martens, in Physics in Medicine and Biology, Volume 55, Issue 18, pp. 5541–5555, September 2010, online August 31

 
PAPERS

23/08/2010

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balzano@itis-usa.org

 

An International Interlaboratory Comparison of Mobile Phone SAR Calculation With CAD-Based Models

Martin Siegbahn, Giorgi Bit-Babik, Jafar Keshvari, Andreas Christ, Benoît Derat, Vikass Monebhurrun, Christopher Penney, Martin Vogel, and Tilmann Wittig, in IEEE Transactions on Electromagnetic Compatibility, Volume 52, Issue 4, pp. 804–811, November 2010, online August 23, 2010

 
PAPERS

01/07/2010

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balzano@itis-usa.org

 

Impact of Pinna Compression on the RF Absorption in the Heads of Adult and Juvenile Cell Phone Users

Andreas Christ, Marie-Christine Gosselin, Sven Kühn, and Niels Kuster, in Bioelectromagnetics, Volume 31, Issue 5, pp. 406–412, July 2010, online March 30

 
PAPERS

16/06/2010

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balzano@itis-usa.org

 

Measured Radiofrequency Exposure During Various Mobile-Phone Use Scenarios

Michael A. Kelsh, Mona Shum, Asher R. Sheppard, Mark McNeely, Niels Kuster, Edmund Lau, Ryan Weidling, Tiffani Fordyce, Sven Kühn, and Christof Sulser, in Journal of Exposure Science and Environmental Epidemiology, Volume 21, Issue 4, pp. 343–354, July/August 2011, advance online publication June 16, 2010

 
PAPERS

31/05/2010

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balzano@itis-usa.org

 

Unstructured Mesh Generation from the Virtual Family Models for Whole Body Biomedical Simulations

Dominik Szczerba, Esra Neufeld, Marcel Zefferer, Gabor Szekely, and Niels Kuster, in Procedia Computer Science, Volume 1, Issue 1, pp. 837–844, May 2010

 
PAPERS

13/05/2010

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balzano@itis-usa.org

 

Assessment of Induced SAR in Children Exposed to Electromagnetic Plane Waves Between 10 MHz and 5.6 GHz

Jurriaan F. Bakker, Margarethus M. Paulides, Andreas Christ, Niels Kuster, and Gerard C. van Rhoon, in Physics in Medicine and Biology, Volume 55, Issue 11, pp. 3115–3130, June 2010, online May 12

 
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