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22/04/2015
Anatomical Model of the Human Head and Neck

MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck

Maria Iacono, Esra Neufeld, Esther Akinnagbe, Kelsey Bower, Johanna Wolf, Ioannis Oikonomidis, Deepika Sharma, Bryn Lloyd, Bertram Wilm, Michael Wyss, Klaas Pruessmann, Andras Jakab, Nikos Makris, Ethan Cohen, Niels Kuster, Wolfgang Kainz, and Leonardo Angelone, PLoS ONE, Volume 10, Issue 4, online April 22, 2015

Computational modelling and simulations are increasingly being used to complement experimental testing for analysis of safety and efficacy of medical devices. We have developed a multimodal imaging-based detailed anatomical model of the human head and neck. The model was obtained by integrating three different magnetic resonance imaging (MRI) modalities, the parameters of which were tailored to enhance the signals of specific tissues: i) structural T1- and T2-weighted MRIs; a specific heavily T2-weighted MRI slab with high nerve contrast optimized to enhance the structures of the ear and eye; ii) magnetic resonance angiography (MRA) data to image the vasculature, and iii) diffusion tensor imaging (DTI) to obtain information on anisotropy and fibre orientation. The unique multimodal high-resolution approach allowed resolving 150 structures, including several distinct muscles, bones and skull layers, arteries and veins, as well as salivary glands. The model offers also a detailed characterization of eyes, ears, and deep brain structures. A special automatic atlas-based segmentation procedure was adopted to include a detailed map of the nuclei of the thalamus and midbrain into the head model. The suitability of the model to simulations involving different numerical methods, discretization approaches, as well as DTI-based tensorial electrical conductivity, was examined in a case-study, in which transcranial alternating current stimulation was modelled.

The scientific and technical impact of the study can be summarized as:

  • Creating and making available a detailed, high-resolution head model distinguishing a large number of tissues
  • Creating high element-quality, topologically conforming, non-intersecting surfaces suitable for structured and unstructured discretization techniques
  • Integrating image-based information to inform on inhomogeneous and anisotropic property distributions
  • Demonstrating the suitability of the head model for a large range of numerical simulation techniques
 
 
 
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PAPERS

15/11/2012

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balzano@itis-usa.org

 

Field Evaluation of the Human Exposure from Multi-Band, Multi-System Mobile Phones

Sven Kühn, and Niels Kuster, IEEE Transactions Electromagnetics Compatibility, Volume 55, Issue 2, pp. 275-287, April 2013, online November 15, 2012

 
PAPERS

01/11/2012

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balzano@itis-usa.org

 

ELF Exposure System for Live Cell Imaging

Myles Capstick, Primo Schär, David Schürmann, Albert Romann, and Niels Kuster, Bioelectromagnetics, online ahead of print November 01, 2012

 
PAPERS

25/10/2012

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balzano@itis-usa.org

 

Evaluation of Wireless Resonant Power Transfer Systems With Human Electromagnetic Exposure Limits

Andreas Christ, Mark G. Douglas, John Roman, Emily B. Cooper, Alanson P. Sample, Benjamin H. Waters, Joshua R. Smith and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 55, Issue 2, pp. 265-274, April 2013, online October 25, 2012

 
PAPERS

16/10/2012

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balzano@itis-usa.org

 

The Effect of Diode Response of Electromagnetic Field Probes for the Measurements of Complex Signals

Jagadish Nadakuduti, Sven Kuehn, Marcel Fehr, Mark Douglas, Katja Pokovic, and Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 54, Issue 6, pp. 1195-1204, December 2012, online October 16

 
PAPERS

11/10/2012

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balzano@itis-usa.org

 

Evaluation of the RF Heating of a Generic Deep Brain Stimulator Exposed in 1.5 T Magnetic Resonance Scanners

Eugenia Cabot, Tom Lloyd, Andreas Christ, Wolfgang Kainz, Mark Douglas, Gregg Stenzel, Steve Wedan, and Niels Kuster, Bioelectromagnetics, Volume 34, Issue 2, pp. 104-113, February 2013, online October 11

 
PAPERS

01/10/2012

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balzano@itis-usa.org

 

Patient-Specific Simulations and Measurements of the Magneto-Hemodynamic Effect in Human Primary Vessels

Adamos Kyriakou, Esra Neufeld, Dominik Szczerba, Wolfgang Kainz, Roger Luechinger, Sebastien Kozerke, Robert McGregor, and Niels Kuster, Physiological Measurement, Volume 33, Issue 2, pp. 117–130, February 2012, online January 6

 
PAPERS

18/06/2012

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balzano@itis-usa.org

 

Mechanisms of RF Electromagnetic Field Absorption in Human Hands and Fingers

Chung-Huan Li, Mark Douglas, Erdem Ofli, Nicolas Chavannes, Quirino Balzano, and Niels Kuster, IEEE Transactions on Microwave Theory and Techniques, Volume 60, Issue 7, pp. 2267–2276, July 2012, online June 26

 
PAPERS

06/06/2012

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balzano@itis-usa.org

 

Sleep EEG Alterations: Effects of Pulsed Magnetic Fields Versus Pulse-Modulated Radio Frequency Electromagnetic Fields

Marc R. Schmid, Manuel Murbach, Caroline Lustenberger, Micheline Maire, Niels Kuster, Peter Achermann, and Sarah P. Loughran, Journal of Sleep Research, Volume 21, Issue 6, pp. 620-629, December 2012, online June 22

 
PAPERS

02/06/2012

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balzano@itis-usa.org

 

A Novel Approach for Mobile Device Design: GA-Based Distributed Optimization to Comply with OTA, SAR, and HAC Standards

Xi Lin Chen, Erdem Ofli, Nicolas Chavannes, and Niels Kuster, IEEE Antennas and Propagation Magazine, Volume 54, Issue 1, pp. 22–31, February 2012, online June 1

 
PAPERS

01/06/2012

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balzano@itis-usa.org

 

Exposure of the Human Body to Professional and Domestic Induction Cooktops Compared to the Basic Restrictions

Andreas Christ, René Guldimann, Barbara Bühlmann, Marcel Zefferer, Jurriaan F. Bakker, Gerard C. van Rhoon, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 8, pp. 695-705, December 2012, online June 1

 
PAPERS

13/03/2012

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balzano@itis-usa.org

 

Children and Adults Exposed to Low Frequency Magnetic Fields at the ICNIRP Reference Levels: Theoretical Assessment of the Induced Electric Fields

Jurriaan F. Bakker, Maarten M. Paulides, Esra Neufeld, Andreas Christ, Xi Lin Chen, Niels Kuster, and Gerard van Rhoon, Physics in Medicine and Biology, Volume 57, Number 7, pp. 1815–1829, April 2012, online March 13

 
PAPERS

13/02/2012

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balzano@itis-usa.org

 

Exposure System to Study Hypotheses of ELF and RF Electromagnetic Field Interactions of Mobile Phones With the Central Nervous System

Manuel Murbach, Maria Christopoulou, Pedro Crespo-Valero, Peter Achermann, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 6, pp. 527–533, September 2012, online February 13

 
PAPERS

20/01/2012

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balzano@itis-usa.org

 

Parallelization of the FDTD Method Based on the Open Computing Language and the Message Passing Interface

Tomasz P. Stefanski, Nicolas Chavannes, and Niels Kuster, in Microwave and Optical Technology Letters, Volume 54, Issue 3, pp. 785–789, March 2012, online January 20

 
PAPERS

10/01/2012

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balzano@itis-usa.org

 

Experimental Evaluation of the SAR Induced in Head Phantoms of Three- and Eight-Year-Old Children

Marie-Christine Gosselin, Sven Kühn, Andreas Christ, Marcel Zefferer, Emilio Cherubini, Jurriaan F. Bakker, Gerard C. van Rhoon, and Niels Kuster, IEICE Transactions on Communications, Volume E95-B, Number 10, pp. 3215–3224, October 2012

 
PAPERS

01/12/2011

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pasche@itis-usa.org

 

Cancer Cell Proliferation is Inhibited by Specific Modulation Frequencies

Jacquelyn W. Zimmerman, Michael J. Pennison, Ivan Brezovich, Nengjun Yi, Celeste T. Yang, Ryne Ramaker, Devin Absher, Richard M. Myers, Niels Kuster, Frederico P. Costa, Alexandre Barbault, and Boris Pasche, British Journal of Cancer, Volume 106, Issue 2, pp. 307–313, January 17, 2012. Online December 1, 2011

 
PAPERS

21/11/2011

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balzano@itis-usa.org

 

Local Tissue Temperature Increase of a Generic Implant Compared to the Basic Restrictions Defined in Safety Guidelines

Adamos Kyriakou, Andreas Christ, Esra Neufeld, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 5, pp. 366–374, July 2012, online November 21

 
OTHER NEWS

18/11/2011

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balzano@itis-usa.org

 

2nd Board Meeting

IT'IS USA held its second board meeting on November 18, 2011.

 
PAPERS

21/10/2011

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balzano@itis-usa.org

 

Influence of the Hand on the Specific Absorption Rate in the Head

Chung-Huan Li, Mark Douglas, Erdem Ofli, Benoit Derat, Sami Gabriel, Nicolas Chavannes, and Niels Kuster, IEEE Transactions on Antennas and Propagation, Volume 60, Issue 2, pp. 1066–1074, February 2012, online October 21, 2011

 
PAPERS

22/09/2011

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balzano@itis-usa.org

 

Local SAR Enhancements in Anatomically Correct Children and Adult Models as a Function of Position within 1.5T MR Body Coil

Manuel Murbach, Eugenia Cabot, Esra Neufeld, Marie-Christine Gosselin, Andreas Christ, Klaas Prüssmann, and Niels Kuster, Progress in Biophysics and Molecular Biology, Volume 107, Issue 3, pp. 428–433, December, 2011. Online September 22

 
PAPERS

31/08/2011

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balzano@itis-usa.org

 

Application of an Induced Field Sensor for Assessment of Electromagnetic Exposure from Compact Fluorescent Lamps

Jagadish Nadakuduti, Mark Douglas, Myles Capstick, Sven Kühn, and Niels Kuster, Bioelectromagnetics, Volume 33, Issue 2, pp. 166–175, February 2012. Online August 31, 2011

 
PAPERS

15/08/2011

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balzano@itis-usa.org

 

Mechano-Chemical Simulation of a Solid Tumor Dynamics for Therapy Outcome Predictions

Sven Hirsch, Dominik Szczerba, Bryn Lloyd, Michael Bajka, Niels Kuster, and Gabor Szekely, International Journal for Multiscale Computational Engineering, Volume 9, Issue 2, pp. 231–241, 2011, online August 15

 
PAPERS

12/08/2011

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balzano@itis-usa.org

 

Head Exposure System for a Human Provocation Study to Assess the Possible Influence of UMTS-Like Electromagnetic Fields on Cerebral Blood Circulation Using Near-Infrared Imaging

Hugo Lehmann, Laurent Pollara, Sonja Spichtig, Sven Kühn, and Martin Wolf, Bioelectromagnetics, Volume 33, Issue 2, pp. 124–133, February 2012. Online August 12, 2011

 
PAPERS

09/08/2011

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Treatment of Advanced Hepatocellular Carcinoma with Very Low Levels of Amplitude-Modulated Electromagnetic Fields

Frederico P. Costa, André Cosme de Oliveira, Roberto Meirelles, Marcel C.C. Machado, Tatiana Zanesco, Rodrigo Surjan, Maria Cristina Chammas, Manoel de Souza Rocha, Desiree Morgan, Alan Cantor, Jacquelyn Zimmerman, Ivan Brezovich, Niels Kuster, Alexandre Barbault, and Boris Pasche, British Journal of Cancer, Volume 105, Number 5, pp. 640–648, August 23, 2011. Online August 9

 
PAPERS

15/07/2011

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balzano@itis-usa.org

 

Children and Adults Exposed to Electromagnetic Fields at the ICNIRP Reference Levels: Theoretical Assessment of the Induced Peak Temperature Increase

Jurriaan F. Bakker, Margarethus M. Paulides, Esra Neufeld, Andreas Christ, Niels Kuster, Gerard C. van Rhoon, Physics in Medicine and Biology, Volume 56, Number 15, pp. 4967–4990, August, 2011, online July 19

 
PAPERS

06/07/2011

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balzano@itis-usa.org

 

Analysis of the Local Worst-Case SAR Exposure Caused by an MRI Multi-Transmit Body Coil in Anatomical Models of the Human Body

Esra Neufeld, Marie-Christine Gosselin, Manuel Murbach, Andreas Christ, Eugenia Cabot and Niels Kuster, Physics in Medicine and Biology, Volume 56, Number 15, pp. 4649–4659, August, 2011, online July 6

 
PAPERS

05/07/2011

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balzano@itis-usa.org

 

Estimation Formulas for the Specific Absorption Rate in Humans Exposed to Base Station Antennas

Marie-Christine Gosselin, Günter Vermeeren, Sven Kühn, Valpré Kellerman, Stefan Benkler, Tero M. I. Uusitupa, Wout Joseph, Azeddine Gati, Joe Wiart, Frans J. C. Meyer, Luc Martens, Toshio Nojima, Takashi Hikaje, Quirino Balzano, Andreas Christ, Niels Kuster, IEEE Transactions on Electromagnetic Compatibility, Volume 53, Issue 4, pp. 909–922, November 2011, online June 9

 
PAPERS

19/04/2011

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balzano@itis-usa.org

 

GPU-Based Simulation of 3D Blood Flow in Abdominal Aorta Using OpenFOAM

Ziemowit Malecha, Lukasz Miroslaw, Tadeusz Tomczak, Zbigniew Koza, Maciej Matyka, Wojciech Tarnawski, and Dominik Szczerba, in Archives of Mechanics, Volume 63, Issue 2, pp. 137–161, April 2011. Paper presented at 19th Polish National Fluid Dynamics Conference (KKMP), Poznan, Poland, September 5–9, 2010, online April 19, 2011

 
PAPERS

12/04/2011

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balzano@itis-usa.org

 

Sleep EEG Alterations: Effects of Different Pulse-Modulated Radio Frequency Electromagnetic Fields

Marc R. Schmid, Sarah P. Loughran, Sabine J. Regel, Manuel Murbach, Aleksandra Bratic Grunauer, Thomas Rusterholz, Alessia Bersagliere, Niels Kuster, and Peter Achermann, Journal of Sleep Research, Volume 21, Issue 1, pp. 50–58, February, 2012, online April 12, 2011

 
PAPERS

17/03/2011

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balzano@itis-usa.org

 

Estimation of Head Tissue-Specific Exposure from Mobile Phones Based on Measurements in the Homogeneous SAM Head

Marie-Christine Gosselin, Sven Kühn, Pedro Crespo-Valero, Emilio Cherubini, Marcel Zefferer, Andreas Christ, and Niels Kuster, Bioelectromagnetics, Volume 32, Issue 6, pages 493–505, September 2011, online March 17

 
PAPERS

02/03/2011

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balzano@itis-usa.org

 

Manycore Stencil Computations in Hyperthermia Applications

Matthias Christen, Olaf Schenk, Esra Neufeld, Maarten Paulides, and Helmar Burkhart, “Manycore Stencil Computations in Hyperthermia Applications,” in “Scientific Computing with Multicore and Accelerators,” Jakub Kurzak, David A. Bader, and Jack Dongarra, Eds., CRC Press, Taylor & Francis Group, Boca Raton, FL, USA, 2011

 
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